The delivery of the suicide herpes simplex virus type 1 thymidine kinase (TK) gene into tumor cells followed by therapy with synthetic guanylic nucleotide analogues, such as gancyclovir and acyclovir, ...
The thymidine kinase (TK) genes from herpes simplex virus (HSV) types 1 and 2 were recombined in vitro with a technique called DNA family shuffling. A high-throughput robotic screen identified ...
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