The Houston Texans eye their third consecutive win when they take on the Buffalo Bills in a key 'Thursday Night Football' matchup. Buffalo is coming off a 44-32 win over the Tampa Bay Buccaneers, while Houston defeated the Tennessee Titans 16-13.

A win would keep Buffalo in the AFC playoff hunt, while a loss could raise serious questions about their postseason hopes. The Bills are favored by 5.5 points, according to BetMGM, with an over/under of 48. A $250 bet on Buffalo to win would net $100, while a $100 wager on Tampa Bay would return $200.

NFL Week 11 odds, picks, predictions, TV channel, streaming information for the Sunday football game between Tampa Bay Buccaneers and Buffalo Bills.

The Tampa Bay Buccaneers and the Buffalo Bills play Sunday in Week 11 at Highmark Stadium in Orchard Park, New York.

The Buffalo Bills traded cornerback Kaiir Elam to the Dallas Cowboys back in March. Sending out a former first-round pick still on their rookie deal is never a good sign. But Buffalo, who also gave Dallas a sixth-round selection in 2025 in the deal, ended up with Round 5 (2025) and Round 6 (2026) picks in the trade.