Fresh off a heartbreaking loss to the Kansas City Chiefs in the AFC Championship Game last season, the Buffalo Bills are set to enter 2025 with Super Bowl aspirations.

We have known the Buffalo Bills’ 2025 opponents since last year’s regular season concluded Jan. 5, and we have known the schedule will include nine home games and eight road games since 2021. But everything else? We won’t know until 8 p.m. Wednesday – at least officially.

The Baltimore Ravens will get an early chance at redemption when the team travels to Highmark Stadium and faces the Buffalo Bills on Sunday Night Football in Week 1.

The Buffalo Bills were already looking good going into the 2025 season, but now they may be looking even better.

The full 2025 NFL schedule, complete with dates and times, is set to be released on Wednesday night May 14th. All 32 teams are already aware of their 17 opponents for the upcoming year and some of them will have much more difficult paths than others. Here are the five teams with the hardest sets of matchups.