Cancer doesn’t follow a linear path—it evolves, adapts, and forks. Even within a single tumor, individual cells behave differently. They mutate, diverge, and form heterogeneous clones that fuel ...

Single-cell technologies uncover how leukemia cells evolve, resist therapy, and survive through cell-to-cell communication.

A study demonstrates that the 'previous state' of blood stem cells plays a decisive role in the subtype of leukemia that develops. The new technique, called STRACK, allows monitoring of the evolution ...

A newly identified and rare genetic variant slows the growth of mutated blood stem cells, researchers report, and it reduces the risk of leukemia. The findings offer insight into why some people are ...

As tissues age, they quietly accumulate many mutations that can drive cancer. In the hematopoietic system, such mutations often appear in otherwise healthy individuals as clonal hematopoiesis (CH), a ...

LA JOLLA, CA—Scientists at La Jolla Institute for Immunology (LJI) have discovered how a mutated gene kicks off a dangerous chain of events during blood cell production. The study, published recently ...

Scientists at La Jolla Institute for Immunology (LJI) have discovered how a mutated gene kicks off a dangerous chain of events during blood cell production. The study, published recently in the ...

A Northwestern Medicine-led study published in the Journal of Clinical Investigation has uncovered why older individuals with specific genetic mutations face a heightened risk of developing serious ...