The second messenger cyclic di-AMP (c-di-AMP) plays a pivotal role in bacterial physiology by regulating osmolyte transport, potassium uptake, cell wall integrity and the overall stress response.

Earl W. Sutherland Jr., former professor and chair of the Department of Pharmacology, led the discovery of cyclic AMP, a cellular signaling molecule responsible for many metabolic processes. He won ...

Tsukuba, Japan—Cyclic molecules are used in a wide range of applications, including molecular sensing, because they can incorporate specific molecules of interest into their inner cavities.