Scientists have discovered a new genetic mutation in mosquitoes that helps them to resist insecticides, a major hurdle to ...

A new study has detected a DNA marker in a gene encoding a key enzyme known as cytochrome P450 that helps mosquitoes to break ...

The cytochrome P450 enzymes form a vast superfamily of haem‐containing monooxygenases that catalyse the metabolism of a broad spectrum of endogenous substances and xenobiotics. Their dynamic catalytic ...

A mutation that causes resistance to pyrethroid insecticides—used in mosquito bed nets—was identified in the Anopheles gambiae mosquito.

Cytochrome P450 enzymes constitute a vast and diverse superfamily of haem‐containing proteins that orchestrate a broad array of oxidative reactions. Their inherent versatility enables them to catalyse ...

A new study, jointly led by Liverpool School of Tropical Medicine and the Centre for Research in Infectious Diseases in Cameroon, has detected a part in the DNA for a key enzyme, known ...

A new study, jointly led by Liverpool School of Tropical Medicine and the Centre for Research in Infectious Diseases (CRID) ...

Phase I study of docetaxel and temsirolimus in refractory solid tumors. Background: Interactions of cytochrome P450 (CYP), especially CYP3A4, between chemotherapy agents and other xenobiotics can ...

Background: Clopidogrel is a prodrug requiring metabolism by cytochrome P450 3A (CYP3A) isoenzymes, including CYP3A5, in order to be active. It is controversial whether clopidogrel interacts with ...