During embryonic stem cell (ESC) development, pluripotent stem cells transition from a naïve state into a primed state before they take their first steps toward a lineage commitment. Jacob Hanna, a ...

The mystery of early embryonic communication is starting to be unraveled thanks to a new stem cell-based model.

Chimpanzee naive pluripotent stem cells (PSCs) can now be grown in cellular cultures, reveals a recent study. They successfully created chimpanzee early embryo models, called 'blastoids,' and found ...

You are the product of metamorphosis. During the third week of your embryonic existence, fateful genetic choices were made that began to transform a tiny ball of identical stem cells into a complex ...

Scientists at the University of California, Santa Cruz (UCSC), used CRISPR to engineer cellular models of embryos that mimic what happens in the first few days after reproductive cells meet. These ...

Although embryonic stem cells (ESCs) have been successfully derived from mice and rats, efforts to establish chimeric and germline-competent ESC lines in species beyond rodents have been unsuccessful.

Which genes are required for turning embryonic stem cells into brain cells, and what happens when this process goes wrong? In ...

Researchers have discovered a key transition in early embryonic development is facilitated by decreasing levels of a viral protein inserted into the DNA of our early animal ancestors. Researchers at ...

A sweeping genetic screen reveals how the brain is built and exposes a hidden gene behind a newly discovered childhood brain ...

Welcome to Lab Dish, a First Opinion column on regenerative medicine from Paul Knoepfler. Twenty years ago, the use of human embryonic stem cells in research was among the most fiercely debated topics ...