Nature

Bisindolylmaleimide VIII facilitates Fas-mediated apoptosis and inhibits T cell-mediated autoimmune diseases

Fas-mediated apoptosis is essential for the elimination of cells, and impaired apoptosis can have severe detrimental consequences. Bisindolylmaleimide VIII potentiated Fas-mediated apoptosis in human ...
ascopubs.org

K1 from human herpesvirus 8 (HHV-8) suppresses Fas-mediated apoptosis and binds to the Fas complex

HAART influences the presenting characteristics and improves the outcome of patients (pts) with Hodgkin’s disease and HIV infection (HD-HIV) No significant financial relationships to disclose. This is ...
BioWorld

New Fas-TNFR chimeras overcome Fas ligand-mediated apoptosis and increase CAR T-cell efficacy

A new study has discovered a promising approach to improve the efficacy of adoptive cell therapies for cancer. The research, published in Molecular Therapy: Nucleic Acids, describes the development of ...
ascopubs.org

Association of FASL and FAS polymorphisms, enrolled in extrinsic apoptosis pathway, with head and neck squamous cell carcinoma risk and outcomes.

Analysis of immune infiltrates in a genomically characterized clinical cohort of head and neck squamous cell carcinoma (HNSCC) patients (pts).
Ophthalmology Times

ONL Therapeutics randomizes first European patient in phase 2 GA trial of Xelafaslatide

Enrollment spans Europe, the US, and Canada, targeting ~324 GA patients in a randomized, double-masked, sham-controlled phase ...