An innovative CRISPR-Cas12f-based activator system may hold significant potential in the future of gene therapy and biological research, suggest researchers of a new study. The study highlights the ...

Scientists at the MRC Laboratory of Medical Sciences (LMS) have discovered a DNA-based “dimmer switch” that regulates the activity of a critical developmental gene, Cdx2. This work could pave the way ...

To help achieve more precise control of gene therapy, engineers have designed a new control circuit that can keep gene expression levels within a target range. The method could be used to deliver ...

Human genes are written in long strings of three-letter units composed of four different nucleotides. These units—or ...

Cells rely on tiny molecules called microRNAs to tune which genes are active and when. Cells must carefully control the lifespan of microRNAs to prevent widespread disruption to gene regulation. A new ...

A new study shows cells use dual RNA signals to control microRNA lifespan. This selective process protects gene regulation while enabling targeted RNA breakdown.

Researchers identify a gene expression program in the living human brain that tracks with real-time neurotransmission, bridging the gap between genetics and electrical brain activity.

Researchers at the School of Biological Sciences of The University of Hong Kong (HKU) have uncovered how eukaryotic cells can control gene activity even after losing one of their major gene-regulatory ...

Much of the phenotypic variation that is observed within and between species is the result of differences in gene regulation: specifically when, where and how much the genes are expressed. Given the ...

Gene regulation is the process by which cells control the expression of their genes, determining when, where, and to what extent each gene is expressed. It is a fundamental mechanism that allows cells ...

Epigenetic therapies are offering a more targeted way to treat some lymphomas by changing how genes are turned on or off ...