Grey's Anatomy' Season 22 premiere reveals a cast departure -- the sole casualty from the massive OR explosion.

The creator of the long-running medical drama opened up about the rude surprise she encountered during a recent — and rare — "Grey's" rewatch.

Shonda Rhimes, in a recent interview, candidly reflected on Grey’s Anatomy. Her remarks reignited interest in the show’s most emotional moments, particularly the shocking death of T.R. Knight’s George O’Malley.

Monica Beltran’s exit from Grey’s Anatomy sent shockwaves through the fandom. The saddest part was that she was not written off gently, but was a victim of an explosion that marked the final moments of Season 21.

Grey’s Anatomy star Natalie Morales opens up about her heartbreaking Season 22 exit as Dr. Monica Beltran. From guest role to fan favorite, her heroic death left viewers in tears

Viewers without cable can watch the latest episodes of “Grey’s Anatomy” live and on demand for free by signing up for trial offers from fuboTV (5-day free trial), DirecTV (5-day free trial) or Hulu + Live TV (3-day free trial).

Season 21 of Grey’s Anatomy ended on a shocking cliffhanger that left the audience wondering about the fate of many of the characters on the ABC drama series. Namely, orthopedic surgeon Dr.

The creator of the legendary medical drama has killed off plenty of major characters over the course of 21 seasons, but this shocker stands apart.

With season 22 now underway, Grey’s Anatomy continues to hold the record as the longest-running medical drama in U.S. history. But how many more seasons can this show churn out? Will there be a season 23 or is this ABC series nearing its very own expiration date?

Grey’s Anatomy Season 22 brings new challenges and heartbreak. Find out the release date, cast lineup, plot updates, and streaming platforms.