Conventional immune checkpoint inhibitors, such as anti-PD-1/PD-L1 and anti-CTLA-4 antibodies, can reinvigorate T cells but ...
(A) CuN is formed by self-assembly of Cu²⁺ and NLG919 via Cu-N coordination bonds, with chemotherapeutic agents (e.g., β-lapachone) encapsulated through hydrophobic interactions. (B) Lap@CuN passively ...
Two junior research groups at Ruhr University Bochum, Germany, have developed a drug complex that kills cancer cells in such a clever manner that they raise a red flag as they die. They signal to the ...
Figure 7: Proposed mode of action of INT-1B3/1B3. INT-1B3/1B3 induces apoptosis and cell death leading to expression of DAMPs, e.g., expression of calreticulin, reduced expression of CD39 and CD73 and ...
Cancer immunotherapy has saved lives, but it often falls short due to off-target toxicity and weak tumor-specific immune ...
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