A cost-effective copper-catalyzed reaction enables selective modification at the C5 position of the indole ring, a backbone for pharmaceutical compounds. Indoles, which form the backbone of many ...

A new chemical reaction pioneered by researchers from the University of Toronto (Toronto, ON, Canada) simplifies the production process for indole rings, a basic molecular frameworks commonly used in ...

A research group at Nagoya University in Japan has successfully developed an ultrafast and simple synthetic method for producing indole derivatives. Their findings are expected to make drug production ...

Figure 1: Summary of applied TAD chemistry for click and transclick reactions. An overview of the possibilities and key aspects of TAD-based chemistry reported here is given in Fig. 1b, which is ...

Indole, a molecule made up of a six-membered benzene ring fused to a five-membered ring containing nitrogen, forms the core structure of many biologically active compounds. Derivatives of indole, ...

The proposed method is simple, mild, fast, and produces high yields, with the potential to inspire the development of new drugs and agrochemicals. Indolo[2,3-a]quinolizidine is a common structural ...

Indole, and structures derived from it, are a component of many natural substances, such as the amino acid tryptophan. A new catalytic reaction produces cyclopenta[b]indoles -- frameworks made of ...

Indole-based alkaloid natural products such as fischerindoles and hapalindoles have promising antimicrobial and antitumor activities, but they are difficult to make synthetically. New findings on how ...

Indoles abound in bioactive molecules. They make up the molecular core of the essential amino acid tryptophan, the sleep-inducing supplement melatonin, and the psychedelic compound psilocybin.