A lupus diagnosis is based on clinical symptoms (past and present), a family history (the medical history of close family members such as your grandparents, parents, siblings, aunts, uncles, cousins) ...
Nearly all people who have systemic lupus erythematosus (SLE) test positive for antinuclear antibody (ANA), but a small number can develop lupus without ANA, known as seronegative or ANA-negative ...
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