Get the opening NFL Week 5 odds with point spreads, Over/Unders, and football moneylines for every matchup starting on Sept. 30.

Your Week 4 NFL betting guide can observe trends from the first three weeks of the season, and just three teams are a perfect 3-0 against the spread.

The Rams travel across the country to take on the Philadelphia Eagles in a matchup of two preseason favorites at betting sites to win their division.