Proteins form the building blocks of life, but when they form unusual clumps inside the brain, they raise an alarm that ...

Neurodegenerative diseases such as Alzheimer's, Parkinson's, Huntington's, and amyotrophic lateral sclerosis (ALS) affect millions of people worldwide, yet treatments remain largely limited to symptom ...

Researchers headed by a team at the Centre for Genomic Regulation, Barcelona Institute of Science and Technology and at the Wellcome Sanger Institute have developed an AI tool that they say has made a ...

The formation of amyloid fibrils and the aggregation of misfolded proteins are central to the pathology of Alzheimer’s disease. At the molecular level, normal proteins adopt aberrant conformations ...

A new large-scale study has mapped the first molecular events that drive the formation of harmful amyloid protein aggregates found in Alzheimer's disease, pointing towards a new potential therapeutic ...

Raghu R. Chivukula, MD, Ph.D., a physician-investigator in the Departments of Medicine & Surgery and the Center for Genomic Medicine at Massachusetts General Hospital and Harvard Medical School, is ...

The pathway leading to the telltale sign of ALS, protein aggregation in the cytoplasm of motor neurons, has been revealed. Researchers from the University of California – San Diego (CA, USA) have ...

Back when James Parkinson first described the disorder now known as Parkinson’s disease, he noticed that severe constipation can be a prelude to the signature tremors. In the 208 years since then, ...

The accumulation of misfolded proteins in the brain is central to the progression of neurodegenerative diseases like Huntington’s, Alzheimer’s and Parkinson’s. But to the human eye, proteins that are ...

Explore why tau still lacks treatments despite its critical role in Alzheimer's disease and other tauopathies.

Researchers have developed a 'self-driving' microscope that can predict the onset of misfolded protein aggregation - a hallmark of neurodegenerative disease - as well as analyze the biomechanical ...