The protein kinase CK2 is involved in a wide range of biological processes and cellular functions, including inflammatory responses and pathologies associated with inflammation. CD8+ T cells, also ...

The AMP-activated protein kinase (AMPK) is a central regulator of cellular energy homeostasis, acting as a metabolic sensor that responds to changes in intracellular AMP/ATP ratios. When cellular ...

Protein kinase CK2 is a highly conserved serine/threonine kinase that plays a pivotal role in multiple cellular processes including cell cycle control, apoptosis suppression, and DNA repair. Elevated ...

Several neurodegenerative diseases begin when toxic protein clumps form in neurons. Scientists have yet to find a good way to clear these clumps from cells. Researchers now report that a ...

As society ages, the number of patients with heart failure is rapidly increasing. The progression of the disease is caused by excessive growth of fibrotic tissue in the heart, known as fibrosis. A ...

Once, researchers thought that only the kinase IKKb--and not its second catalytic subunit, IKKa--had a direct role in activating NF-kB, the much-studied transcription factor that is implicated in ...

CDK2-mediated TBK1 degradation via Dtx4 represents a previously unrecognized regulatory mechanism that modulates antiviral immunity in fish.

A comprehensive mini-review published today after peer review in Brain Medicine by Dr. Tao Ma and colleagues at Wake Forest University School of Medicine synthesizes emerging evidence that two ...

Few effective treatments exist to treat neurodegenerative diseases such as Alzheimer's disease (AD), Parkinson's disease (PD), and amyotrophic lateral sclerosis (ALS). 1 Existing treatments focus on ...

Wheat is grown over more land area than any other food crop. Among pathogen-driven threats to wheat, fungi top the list, causing billions of dollars of losses each year and posing a serious challenge ...