Platform combines proprietary AI sequence optimization, novel genetic parts, and lab validation in application-relevant cell models to improve expression and half-life, delivering top candidates in ...

A metabolic enzyme studied for over seven decades has a hidden second function—it can unwind RNA and promote cell cycle progression, an additional function beyond its role in energy production, ...

RNA viruses frequently bypass the conventional 5′ cap‐dependent mechanism of translation by employing alternative strategies that enable them to commandeer the host’s translational machinery. A ...

Researchers are redesigning lipid nanoparticles to do more than shuttle mRNA into cells, with preclinical studies suggesting ...

Inosine is a nucleoside that occurs naturally in transfer RNAs (tRNAs) and is essential for proper RNA translation. It is commonly found at the wobble position of anticodons, allowing for greater ...

Cancer, a disease with global impact, is intricately linked to dysregulated gene expression, which is influenced by both genetic mutations and epigenetic changes, including RNA modifications. A ...

Chronic neuropathic pain in mice is maintained by the translation of messenger RNA in inhibitory neurons, so drugs that modulate translational pathways may be able to treat this condition.

An interdisciplinary research team from two working groups at the Center for Synthetic Biology at TU Darmstadt has developed ...

Cancer, a disease with global impact, is intricately linked to dysregulated gene expression, which is influenced by both genetic mutations and epigenetic changes, including RNA modifications. A ...

A metabolic enzyme also binds and unwinds RNA to promote translation of cell cycle genes. This dual role links energy status ...

This image illustrates the process of gene transcription within a cell. The DNA double helix unwinds to expose a specific sequence, allowing RNA polymerase to synthesize a complementary pre-mRNA ...