Figure 1: Effect of PBN on thalidomide-initiated DNA oxidation in pregnant rabbits. In contrast, in mice, which are not sensitive to thalidomide teratogenicity, thalidomide did not enhance DNA ...
Pyruvate formate-lyase (PFL) from Escherichia coli uses a radical mechanism to reversibly cleave the C1-C2 bond of pyruvate using the Gly 734 radical and two cysteine residues (Cys 418, Cys 419). We ...
The latest short science news items from C&EN. The team proposes that SAM plays a dual role in the reaction. It donates a methyl group to the enzyme’s cobalamin cofactor and then serves as a base when ...
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