Ribonucleotides are frequently misincorporated into DNA during replication, arising from imperfect sugar discrimination by DNA polymerases and high intracellular ribonucleotide triphosphate pools.

Eukaryotic chromosomes replicate from multiple discrete loci termed origins of replication. These sites are first recognised by the origin recognition complex (ORC), which, together with Cdc6 and Cdt1 ...

The DNA packed inside every human cell contains instructions for life, written in billions of letters of genetic code. Every time a cell divides, the complete code, divided among 46 chromosomes, must ...

Every time a cell divides, it must copy its DNA with extraordinary precision. But this process is constantly challenged by DNA damage. Among the most dangerous lesions are DNA interstrand crosslinks ...

Researchers have gained a clearer insight into how common alterations to the structure of DNA affect the process of DNA replication. These structural changes can put a stop to replication, causing ...

New findings suggest the end-replication problem, an old standby of biology textbooks, is twice as intricate as once thought. Half a century ago, scientists Jim Watson and Alexey Olovnikov ...

Researchers shed new light on G-quadruplexes, a type of secondary DNA structure that has attracted attention as a potential therapeutic target in cancer. Every day, billions of cells in your body ...