President and CEO Adrian Gottschalk said the company was built around the idea that chromatin regulation—and specifically the BAF (SWI/SNF) chromatin remodeling complex—represents a broad and clinical ...
Scientists discovered how macrophages, which act as the immune system's first line of defense, tailor their specific responses to various intruders through the independent and cooperative functions of ...
The SWI/SNF protein complex was already known to carry out such changes, but it was unclear whether each of the three variants did so in a unique way or led to distinct macrophage behavior. To learn ...
The FIPO23 trial: First-in-human phase I/II study of XON7 in advanced solids tumors. ATHENA: A phase 1/2 study of AZD5851, a chimeric antigen receptor (CAR) T-cell therapy directed against GPC3 in ...
Three SWI/SNF protein complex variants, cBAF, ncBAF, and PBAF, gather around a campfire roasting marshmallows, with sashes symbolizing their different but cooperative identities. Together, they ...
Salk scientists determine how three variants of a protein complex coordinate pathogen-specific immune responses in mice; findings may lead to new therapeutics for inflammation LA JOLLA (June 5, ...
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