Senescent cells walk a tightrope, risking cell death with high levels of iron and other damaging agents, but compensating for this by overproducing a protective protein, GPX4, which staves off death.

Cell senescence — a state of irreversible cell-growth arrest — has important physiological functions and is a key driver of ageing. The articles in this Focus explore the molecular mechanisms that ...

A new set of drugs exploit a recently-revealed weakness in 'zombie-like' – or senescent – cells that could lead to new ...

Chemotherapy kills cancer cells, but it also leaves behind something troubling: damaged cells that stop dividing yet refuse ...

Cellular senescence is a state where cells permanently stop dividing but remain metabolically active, often in response to stress or damage. Senescent cells are known to play a key role in wound ...

Most of us think about aging as something that happens to us gradually, almost invisibly, like the slow fading of a ...

Triple-negative breast cancer (TNBC), particularly the luminal androgen receptor (LAR) subtype, presents significant ...

New Preclinical Data on STX-1, a First-in-Class Senolytic ADC, To Be Presented at AACR 2026 Presentations highlight therapy-induced senescence as a new therapeutic opportunity and reinforce the ...

Researchers built an immune-aging clock from 1.2 million cells, revealing T cells as key indicators of immune aging. They ...

Researchers investigating a widely used medication have uncovered an unexpected cellular process that may interfere with ...