Mutations in 3 genes (SPG4, SPG3, and SPG31) are implicated in one half of the autosomal dominant hereditary spastic paraplegias, which are part of the larger group of hereditary spastic diplegias ...

Motor neuron diseases, such as amyotrophic lateral sclerosis (ALS) and hereditary spastic paraplegia (HSP), share physical ...

When Mila Wood turned three years old this past June, her parents were concerned about how far behind she was developmentally from her twin sister.

Hereditary Spastic Paraplegia (HSP) encompasses a heterogeneous group of genetic neurodegenerative disorders primarily characterised by progressive lower-limb spasticity and weakness. The condition ...

Hereditary spastic paraplegias (HSP) are a group of hereditary diseases that result in progressive loss of motor function in the lower limbs, and mutations in many different genes have been implicated ...

Hereditary spastic paraplegia (HSP) is the name given to a group of inherited neurological disorders characterized by progressive stiffness or tightness of the muscles (spasticity) in the lower limbs.

Boston Children's Hospital has received $8.1M in NIH funding to support and expand the Spastic Paraplegia Centers of ...

A gene mutation linked to hereditary spastic paraplegia, a disabling neurological disorder, interferes with the normal breakdown of triglyceride fat molecules in the brain, scientists have found. The ...

The Qiang Laboratory concentrates on using human induced pluripotent stem cell (hiPSC) based technologies to establish in vitro (distinct phenotypical CNS neuronal cultures) and ex vivo (3d forebrain ...

TUCSON, Ariz. (KGUN) — Sitting in his wheelchair, junior at Catalina Foothills High School Ethan Bennett was pushed onstage by his partner Lily Rhodes. While he can move around, he can't walk or talk.