Agents that target the mitotic spindle to disrupt cell division, such as taxanes and vinca-alkaloids, are widely used as anticancer drugs. As these drugs target microtubules, which have a wide variety ...

The ADEBAR trial: Final toxicity analysis of a phase III study evaluating the role of docetaxel in the adjuvant therapy of breast cancer patients with extensive lymph node involvement No significant ...

New research sheds light on embryonic mitosis, thanks to a combination of novel imaging techniques, CRISPR/Cas9 genome editing technology, a modern protein-knockdown system, and medaka, or Japanese ...

Mitotic segregation of chromosomes depends on correct assembly of the bipolar spindle and mitosis is delayed by the spindle assembly checkpoint (SAC). In the July 19 Nature, Gachet et al., at the ...

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Timelapse of a gene-edited medaka fish embryo undergoing mitosis. The mitotic spindle – the green strands in the middle of the cells – can be seen aligning and segregating duplicated chromosomes, ...