Cells have evolved careful checks to ensure DNA is copied only once, but how they switch on replication at the right moment has been the focus of a 30-year research question. New work from the Crick ...

Every time a cell divides, it must accurately copy its entire genetic instruction manual. Before this process can begin, cells load their DNA-copying motor—a complex of six subunits known as the ...

DNA replication in eukaryotic cells is a highly coordinated, multi-step process that ensures precise duplication of the genome prior to cell division. In late mitosis and early G1 phase, the Origin ...

Structural view of the MCM2-7 helicase with Sld3, Sld7 and Cdc45 bound at the site where Cdc45 is delivered. Structure derived from cryogenic electron microscopy data. Noguchi et al., 2026.

Before a cell divides, its DNA is replicated so that each daughter cell inherits the same genetic information. The two copies, known as "sister chromatids," are held together by a ring-shaped protein ...

King Abdullah University of Science & Technology (KAUST)Mar 19 2025 Reviewed For the first time, scientists have witnessed the very moment DNA begins to unravel, revealing a necessary molecular event ...

Embryonic stem (ES) cells are pluripotent stem cells that can produce all cell types of an organism. ES cells proliferate rapidly and have been thought to experience high levels of intrinsic ...