Because synapses are responsible for passing information between neurons, these connections are vital for communication within and outside the brain. Therefore, understanding how they form, function, ...

Clinical portfolio, informed by deep and novel synapse biology and pharmacology insights, aims to strengthen neural connections through event-driven pharmacology Lead candidate zelquistinel is ...

Representative cryo-electron microscopy image: a coloured image of the 3D structure of gephyrin, which was calculated from the data. A team of scientists from the University of Cologne’s Institute of ...

Alzheimer’s may destroy memory by flipping a single molecular switch that tells neurons to prune their own connections. Researchers found that both amyloid beta and inflammation converge on the same ...

Vesicle recycling in the presynaptic terminal at one end of a neuron, showing the role of dynamin during the last step of endocytosis (membrane retrieval), where the protein cuts off the vesicle from ...

The ability to regrow lost synapses can be life changing; for Derek Small, cofounder and CEO of the start-up Syndeio Biosciences, it holds personal relevance. Around a decade ago, Small watched his ...

Fruit flies are excellent research models, in part because it is so easy and inexpensive to raise them, and also because they are so well characterized. The DNA of these insects is estimated to be ...

As we age, we begin to lose the connections that wire up our brains-and neuroscientists aren't sure why.