Li-Fraumeni syndrome is a rare hereditary disease that significantly increases the risk of developing cancer. Almost all ...

Mutations in the tumor suppressor TP53 are a common cause of cancer, making the altered protein an attractive target for therapeutics. Among them, the Y220C mutation is the ninth most frequent and it ...

Much of pancreatic cancer’s evasive and deadly nature may come down to low levels of one gene. In A Nutshell Early detection, late impact: Scientists found that a gene called CTDNEP1 shows reduced ...

Some children have already died and only a minority who inherit the mutation will escape cancer, a new report stated on Wednesday, Dec. 10 Becca Longmire is a digital news writer-reporter at PEOPLE.

MPN-BP transformation is driven by sequential mutations disrupting genomic stability, with TP53 mutations being strong predictors of progression. TP53 mutations confer a selective growth advantage, ...

Mutations in the TP53 gene occur in approximately half of human cancer types, with the TP53 Y220C mutation found in 1% of all solid tumors. Researchers from PMV Pharmaceuticals Inc. and collaborators ...