Explore the role of transcription factor biology in drug discovery and how it impacts our understanding of disease mechanisms ...

Transcription factors are the most powerful genes in our body. They are master regulators and have been implicated in our biggest diseases, even aging itself. Yet, many in the pharmaceutical industry ...

A new CRISPR-based approach for tuning gene expression up and down allowed identification of how other genes' expression responds to changes of transcription factors.

Bioengineers have developed a generalizable method to address 'off-target' binding, a significant problem in the field of synthetic biology. Taking a cue from nature, the researchers showed they could ...