Planar cell polarity (PCP) mechanisms orchestrate the uniform orientation of cells within the plane of a tissue, playing a pivotal role in embryonic development, tissue organisation and the ...

The noncanonical Wnt/PCP pathway. The binding of Wnt ligands leads to the phosphorylation of Dvl, which recruits Invs, Par6, and Smurf. Smurf ubiquitinates the inhibitory protein Prickle, targeting it ...

Researchers from Tel Aviv Sourasky Medical Center presented data from a study that aimed to investigate the genetic mechanisms underlying yellow nail syndrome (YNS), a rare disorder characterized by ...

Hepatocellular carcinoma (HCC) is one of the deadliest cancers globally, with increasing incidence and mortality rates. It arises from chronic liver diseases, including hepatitis B or C infections, ...

A new study reveals why some pancreatic and colorectal tumors resist targeted anti-Wnt drugs and suggests how to overcome it, offering new hope to patients with fully treatment-resistant cancers.