While RNA is formed from just four bases, or nucleotides, its structure and function can be altered by complex biochemical interactions with other compounds. One such compound that modifies mRNA is ...

The goal of my laboratory is to define the sequence-structure-function relationships that underpin mRNA regulation and non-coding function in cells. We aim to translate our findings into mechanistic ...

The popularity of mRNA-based therapeutics has surged over the past few years. To ensure the safety of these treatments, scientists need to analyze the characteristics of the manufactured molecules, ...

As research on the structure and function of RNAs has rapidly expanded, so too has the number of oligonucleotide drugs in clinical development that regulate RNA. This article describes several exam ...

Scientists used IBM's R2 Heron quantum processor to predict the secondary protein structure of a 60-nucleotide-long mRNA sequence.

Researchers from Tokyo Metropolitan University and RIKEN CSRS have developed a new analytical platform based on liquid chromatography, mass spectrometry and software analysis that quantifies the ...

Researchers in Yale’s Gilbert lab published research on mRNA nucleotide modifications and ribosome recruitment, winning a $1.7 million grant from Pfizer.

We report that mice lacking the heterogeneous nuclear ribonucleoprotein U (hnRNP U) in the heart develop lethal dilated cardiomyopathy and display numerous defects in cardiac pre-mRNA splicing. Mutant ...