Fixing the defense will be difficult with Fred Warner and Nick Bosa out for the season but the 49ers are hopeful that quarterback Brock Purdy and receivers Ricky Pearsall and Brandon Aiyuk can return from injuries soon to boost an offense that ranks 26th in the league in scoring.

The long string of injuries that have haunted the San Francisco 49ers all season finally became too much to overcome for at least one week. The defense missing its top two players couldn’t get off the field,

The San Francisco 49ers have waived offensive lineman Drew Moss and signed defensive end Clelin Ferrell to the team's practice squad. News of Ferrell's signing was first reported on Tuesday. The 49ers Communications staff provided the following rundown. Ferrell (6-4, 265)...

En partido de la Semana 8, los San Francisco 49ers cayeron ante los Houston Texans por marcador de 15 a 26. Miguel Pasquel nos cuenta sus impresiones de este encuentro.

Kyle Shanahan provided a series of injury updates after San Francisco fell to the Houston Texans on Sunday afternoon.

The San Francisco 49ers suffered their third defeat of the season on Sunday, losing 26-15 to the Houston Texans. The performance highlighted major areas for im

The San Francisco 49ers dropped their third game of the season on Sunday, falling short 26-15 on the road to the Houston Texans in a rough game on both sides of the ball.

The San Francisco 49ers got Alfred Collins back late in the second quarter against the Texans and almost immediately lost another defensive lineman.