Binding of aminoglycoside antibiotics to 16S ribosomal RNA induces a particular structure of the decoding center and increases the misincorporation of near-cognate amino acids. By kinetic analysis we ...
During protein synthesis, the genetic information stored in DNA is first transcribed into mRNA. The mRNA then travels to the ribosome, where translation occurs. Here's how anticodons facilitate the ...
Proceedings of the National Academy of Sciences of the United States of America, Vol. 104, No. 26 (Jun. 26, 2007), pp. 10824-10829 (6 pages) In universal-code eukaryotes, a single-translation ...
When a ribosome cruises along messenger RNA (mRNA), it may stall at a particular codon, depending on which codons are nearby. In other words, codon context can influence the efficiency with which mRNA ...
Proceedings of the National Academy of Sciences of the United States of America, Vol. 69, No. 10 (Oct., 1972), pp. 3014-3018 (5 pages) The tritiated trinucleotide UGA was used in a binding assay to ...
A research team from the Engelhardt Institute of Molecular Biology in Russia have shown that Nsp1 – a non-structured protein present in the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ...
tRNAs have a distinct cloverleaf secondary structure and an L-shaped tertiary structure. The cloverleaf structure is formed by the folding of the single-stranded tRNA molecule, which is typically ...
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