To make horses rideable during domestication, people may have inadvertently targeted a mutation in horses to strengthen their backs and their balance.

Domestication of the horse was one of the crowning achievements of early humans. It led to advancements in transportation, ...

Conclusions: The cobas mutation tests are robust and reproducible assays that, 1) detects a higher incidence (13.4%) of mutations in codons 12, 13, and 61 of the KRAS gene in wild-type mCRC population ...

As an example, the codon CGA instructs a tRNA to transfer the amino acid arginine to the ribosome. A common genetic mutation converts CGA to UGA, turning an arginine codon into a premature stop codon.