Researchers in the Trimmer Lab at the UC Davis School of Medicine have discovered that mysterious clusters of proteins found on neurons are calcium-signaling “hotspots” that activate gene ...

Somatostatin, a signaling molecule produced by many inhibitory neurons in the brain, broadly dampens communication among a variety of cell types in the prefrontal cortex and promotes exploratory ...

A Purdue University study shows that Notch signaling, a key biological pathway tied to development and cell communication, also plays an important role in the onset of obesity and Type 2 diabetes, a ...

In the first type of signaling pathway, bacteria use the same sensor and effector proteins, cGAS and STING, to respond to phages as humans use to respond to DNA viruses (e.g., smallpox-like viruses).

Drugs that inhibit Notch signaling, called gamma secretase inhibitors, are currently in clinical trials for T-cell leukemia and Alzheimer's disease.

Methods: OncoSignal was used to measure activity of signaling pathways on Affymetrix transcriptome data from sporadic DF (n = 128), generated before in our center (GEO database: GSE58697), and from ...

Study: USP22 controls type III interferon signaling and SARS-CoV-2 infection through activation of STING. Image Credit: Juan Gaertner / Shutterstock This news article was a review of a preliminary ...

In a paper published in Diabetes, they show that, in Type 1 diabetes patients, verapamil prevented the decline of the hormone insulin-like growth factor 1, or IGF-1, as compared to controls who did ...

Somatostatin, a signaling molecule produced by many inhibitory neurons in the brain, broadly dampens communication among a variety of cell types in the prefrontal cortex and promotes exploratory ...