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Cyclin-dependent kinases (CDKs) are an attractive class of cancer targets due to their role in cell-cycle regulation. CDK2 is a Ser/Thr kinase activated via interaction with its cyclin partners CCNE ...

Introduction: There is a need for ADC payloads with an improved therapeutic index, consequently we have coupled potent and selective inhibitors of NMT to trastuzumab to test their potential in both in ...

TenSixty Biosciences employs an innovative AI-enhanced multi-omics discovery framework to enable the development of next-generation antibody-drug conjugates (ADCs). This integrated approach identified ...

Cancer Discov (2026) 16 (7): OF1.

Cancer Discov (2026) 16 (7): OF1.

Abstract. Glucocorticoid receptor (GR) signaling is critical to our physiology but is dysregulated in cancer by the pain, psychologic distress, iatrogenic morbidity, and pathology associated with an ...

Cancer Discov (2026) 16 (7): OF1.

Cancer Discov (2026) 16 (7): OF1.

Cancer Discov (2026) 16 (7): OF1.