BMJ

BCMA-CD19 compound CAR T cells for systemic lupus erythematosus: a phase 1 open-label clinical trial

Objectives This study aims to evaluate the safety and efficacy of BCMA-CD19 compound chimeric antigen receptor T cells (cCAR) to dual reset the humoral and B cell immune system in patients with ...
BMJ

Studies with pain rating scales.

Good correlation has been shown between pain scores derived from 4 different rating scales. The correlation was maintained when presentation of the scales was separated by a series of questions and by ...
BMJ

SAT0405 A Systematic Review of Comparative Efficacy of Various Corticosteroid Preparations for Intra-Articular and Soft Tissue Injections

Background Corticosteroid (CS) injections are commonly used to treat musculoskeletal pain and inflammation. The comparative efficacy of various CS preparations used for such injections has not been ...
BMJ

Imaging research results from the Osteoarthritis Initiative (OAI): a review and lessons learned 10 years after start of enrolment

The Osteoarthritis Initiative (OAI) is a multicentre, prospective, observational, cohort study of knee osteoarthritis (OA) that began recruitment in 2004. The OAI provides public access to clinical ...
BMJ

A4.03 The GPR22 receptor, genetically linked to osteoarthritis stimulates chondrocyte hypertrophy and decreases protein kinase a activity

Purpose A genome-wide association study (GWAS) identified an association between osteoarthritis and a gene cluster on chromosome 7 in which we proposed a role for G protein coupled receptor (GPR)22.
BMJ

X-linked inhibitor of apoptosis protein (XIAP) inhibition in systemic sclerosis (SSc)

Objective X-linked inhibitor of apoptosis protein (XIAP) is a multifunctional protein with important functions in apoptosis, cellular differentiation and cytoskeletal organisation and is emerging as ...
BMJ

Pulse versus daily oral cyclophosphamide for induction of remission in ANCA-associated vasculitis: long-term follow-up

3 Competence Centre for Clinical Research, Skane University Hospital, Lund, Sweden 4 Department of Nephrology and Transplantation, Skane University Hospital Malmö, Lund University, Sweden Introduction ...
BMJ

Controlled clinical trial of IV cyclophosphamide versus IV methylprednisolone in severe neurological manifestations in systemic lupus erythematosus

1 Clinical Epidemiology Research Unit, Hospital Especialidades, Centro Médico Nacional Instituto Mexicano del Seguro Social, Mexico 2 Internal Medicine Department, Centro Médico Nacional Instituto ...
BMJ

AB0411 Rapid Reduction of Antibodies and Improvement of Disease Activity by Immunoadsorption in Chinese Patients with Severe Systemic Lupus Erythematosus

Background Immunoadsorption (IAS) has been used to treat patients with SLE for many years. Efficacy was proved for case report or series with SLE after IAS treatment, while case-control studies are so ...
BMJ

Assessing the performance of AI chatbots in answering patients’ common questions about low back pain

Objectives The aim of this study was to assess the accuracy and readability of the answers generated by large language model (LLM)-chatbots to common patient questions about low back pain (LBP).
BMJ

Cure as a treatment target in rheumatoid arthritis and systemic sclerosis—achievable aim or mission impossible? FOREUM stimulates new industry-academia collaboration

The past 25 years have witnessed a remarkable revolution in outcomes for patients living with rheumatoid arthritis (RA). Historically, uncontrolled joint inflammation was commonplace leading to ...
BMJ

EULAR recommendations for the treatment of systemic sclerosis: 2023 update

Objectives To update the 2017 European Alliance of Associations for Rheumatology (EULAR) recommendations for treatment of systemic sclerosis (SSc), incorporating new evidence and therapies. Methods An ...