Journal of Nuclear Medicine April 2026, jnumed.126.272204; DOI: https://doi.org/10.2967/jnumed.126.272204 ...

The purpose of this study was to compare 18 F-FDG PET/CT and CT performance in guiding percutaneous biopsies with histologic confirmation of lung lesions. Methods: We prospectively evaluated 341 ...

The necessity for standardization in clinical PET/CT protocols was acknowledged and initiated nearly 20 y ago (1–4). This recognition mainly stemmed from multicenter trials focused on quantifying and ...

Planar ventilation–perfusion (V/Q) scanning is often used to investigate pulmonary embolism; however, it has well-recognized limitations. SPECT overcomes many of these through its ability to generate ...

Bone metastases are common, especially in more prevalent malignancies such as breast and prostate cancer. They cause significant morbidity and draw on health-care resources. Molecular and hybrid ...

Objectives: Hemophagocytic lymphohistiocytosis (HLH) is a rare, but life-threatening, multi-organ disorder caused by immune system dysregulation. Diagnosis is challenging due to relatively nonspecific ...

Introduction: Infections in Cardiovascular Implantable Electronic Device (CIED) are complications that pose extreme health risks to patients with implants such as pacemakers and defibrillators.

Journal of Nuclear Medicine May 2026, jnumed.125.271093; DOI: https://doi.org/10.2967/jnumed.125.271093 ...

Inflammatory bowel diseases (IBDs) in humans are characterized in part by aberrant CD4-positive (CD4+) T-cell responses. Currently, identification of foci of inflammation within the gut requires ...

Improved imaging modalities are needed to accurately stage patients with muscle-invasive bladder cancer (MIBC) and metastatic urothelial carcinoma. Imaging with small-molecule ligands or inhibitors of ...

PSMA-targeted radiopharmaceutical therapy (RPT) is a standard treatment for metastatic castration-resistant prostate cancer (PCa), exploiting PSMA overexpression to deliver cytotoxic radiation.

See an invited perspective on this article on page 466. We believe that the PSMA-RADS system is most useful for the categorization of lesions outside the prostate. The reason for that is twofold.