This is a preview. Log in through your library . Abstract This paper proposes a modification of the Fisher-Scoring method, an algorithm which is widely used for computing maximum likelihood estimates, ...

The paper investigates the structure of the self-consistent estimators (SCE) and the nonparametric maximum likelihood estimator (NPMLE) for doubly censored data. An explicit sufficient and necessary ...

The rapid accumulation of genome sequence data has made phylogenetics an indispensable tool to various branches of biology. However, it has also posed considerable statistical and computational ...

For decades, geneticists have used programs to compute back through tens of millions of years of mutations to ancestral genes. Are the algorithms really working? A novel lab physical benchmark says ...