RNA is key to the dark matter of the genome − scientists are sequencing it to illuminate human health and disease

Researchers are embarking on the RNA equivalent of the Human Genome Project, including sequencing all the chemical modifications that make cells unique.
GitHub

PLAID (Protein Latent Induced Diffusion)

PLAID is a multimodal generative model that can generate protein sequence and all-atom structure based on conditional function and taxonomic prompts. Please see our ...
ScienceCodons

Atomic Composition Protein Calculator

Our Atomic Composition Protein Calculator provides a precise elemental breakdown of your protein sequence. By simply inputting a sequence, this tool calculates the exact number of Carbon (C), Hydrogen ...
eLife

The Lipocone Superfamily: A Unifying Theme In Metabolism Of Lipids, Peptidoglycan And Exopolysaccharides, Inter-Organismal Conflicts And Immunity

This fundamental study presents a compelling and comprehensive analysis of the newly defined Lipocone superfamily, offering unprecedented insights into the evolutionary origins of Wnt proteins. The ...
GitHub

Protein Sequence Modelling with Bayesian Flow Networks

Welcome to the inference code for the paper "Protein Sequence Modelling with Bayesian Flow Networks". With this code, you can sample from our trained models ProtBFN, for general proteins, and AbBFN, ...
GEN

Protein Language Model Hits Undruggable Targets, No Structure Required

Pranam Chatterjee, PhD, assistant professor of bioengineering at the University of Pennsylvania (UPenn), emphasizes that text is all you need for artificial intelligence (AI) models to effectively ...
ScienceCodons

Protein Extinction Coefficient Calculator

Our Protein Extinction Coefficient Calculator is a comprehensive, web-based tool for analyzing the essential biochemical and physical properties of your protein sequences. By simply inputting a ...
Microsoft

Accelerating protein engineering with fitness landscape modeling and reinforcement learning

Protein engineering holds significant promise for designing proteins with customized functions, yet the vast landscape of potential mutations versus limited lab capacity constrains the discovery of ...
eLife

Reliable protein–protein docking with AlphaFold, Rosetta, and replica exchange

The authors report how a previously published method, ReplicaDock, can be used to improve predictions from AlphaFold-multimer (AFm) for protein docking studies. The level of improvement is modest for ...
New York Magazine

Everyone Is Cheating Their Way Through College

This article was featured in One Great Story, New York’s reading recommendation newsletter. Sign up here to get it nightly. Chungin “Roy” Lee stepped onto Columbia University’s campus this past fall ...
IEEE

Protein-Protein Interaction Prediction Based on Sequence Data by Support Vector Machine with Probability Assignment

Abstract: In this paper, we investigate the sequence-based protein-protein interaction prediction by machine learning methods. Specifically, we propose to build classifiers in the space of domain ...