The SportsLine projection model reveals its picks for the NFL Week 1 game between the New Orleans Saints and the Arizona Cardinals on Paramount+

Kyler Murray threw two touchdown passes and the Arizona Cardinals narrowly held on for a 20-13 victory over penalty-prone New Orleans on Sunday in the Saints’ first game under rookie coach Kellen Moore.

The Arizona Cardinals got their season underway with a road win over the New Orleans Saints. Here are key takeaways from an encouraging afternoon.

Now, it has turned its attention to the latest Week 1 NFL schedule and locked in its Week 1 survivor pool pick. You can only see who the model is backing this week at SportsLine. New users can also target the DraftKings promo code, which offers $300 in bonus bets instantly plus over $200 off NFL Sunday Ticket:

What went right in Saints vs. Cardinals, and what went wrong? And what's the bottom line? Instant analysis from a tough Week 1 loss:

Arizona Cardinals quarterback Kyler Murray is entering a pivotal 2025 NFL campaign in which he may have to prove that he is actually a franchise player in the desert moving forward, but things could be getting off to a rocky start.

The Arizona Cardinals will be without safety Joey Blount and rookie Cody Simon the rest of the way against the New Orleans Saints.

New Orleans Saints kicker Blake Grupe ties the game at 10-10 with a 36-yard field goal in the second quarter against the Arizona Cardinals.