The son of Deion Sanders and the AP All-American selection was widely viewed by the media as a potential top-five pick, but ended up sliding to pick No. 144. In addition to being the fifth quarterback taken overall, he was the second one taken by the Browns, who also drafted Oregon's Dillon Gabriel with pick No. 94.

The Sanders family was featured on a livestream throughout the 2025 draft as Shedeur, initially projected as a potential first-round pick, fell to the Cleveland Browns in Round 5. Shilo then signed with the Tampa Bay Buccaneers as an undrafted free agent.