AbstractUveal melanoma is an aggressive tumor type that frequently results in fatal liver metastasis. A better understanding of the interactions between uveal melanoma and host cells in the tumor ...
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Abstract:. In the phase I inMMyCAR study of the in vivo chimeric antigen receptor (CAR) T-cell therapy KLN-1010, all 18 patients with multiple myeloma responded. None of the evaluable patients had ...
Abstract:. The treatment arsenal for small cell lung cancer could soon include antibody–drug conjugates, with early data from three phase I studies indicating robust response rates to CD56-targeting ...
AbstractChimeric antigen receptor (CAR) T-cell therapy has shown early promise against glioblastoma, which lacks effective treatment options. However, two key challenges curtail efficacy: ...
AbstractDespite the availability of RAS inhibitors and the dependence of >90% of pancreatic ductal adenocarcinomas (PDAC) on oncogenic KRAS mutations, resistance to KRAS inhibition remains a serious ...
AbstractAnalysis of tumors using single-cell and spatial modalities is critical to advance our understanding of cancer. The growth of technologies that enable these studies provides an increasing ...
Cancer Discov (2026) 16 (6): OF1.
Abstract. Aneuploidy is a hallmark of human tumors. While patient-level copy number alteration (CNA) differences have been investigated extensively in large cohorts, their intratumoral heterogeneity ...
Ming Li Han Liang Jonathan Licht De-Chen Lin Hui-Kuan Lin Piro Lito David Lyden Conor C. Lynch Mathieu Lupien Li Ma Anant Madabhushi Andriy Marusyk Massimiliano Mazzone John D. Minna Lindsay M. Morton ...
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