GutOpinion

Conclusions in search of a confirmatory analysis: the evidence does not yet justify routine proton pump inhibitors after endoscopic variceal ligation

The trial by Yadav and colleagues concludes that proton pump inhibitors (PPIs) should be continued routinely after endoscopic ...
Gut

Risk-based pathology reporting after endoscopic submucosal dissection for early gastrointestinal cancer: international consensus standards

Background Endoscopic submucosal dissection (ESD) enables en bloc resection of early gastrointestinal cancers and provides ...
Gut

Serum creatinine as both yardstick and predictor: reading chronic kidney disease in the global CLEARED cohort

We read the global analysis of chronic kidney disease (CKD) in cirrhosis by Wong et al with great interest.1 Assembling 7040 ...
Gut

Decoding intestinal metaplasia: a step towards understanding gastric tumourigenesis

Tissue epithelia maintain their lineage identity under normal conditions but occasionally undergo ‘reprogramming’ into ...
gut.bmj

Twenty-four-week anti-PD-1 antibody regimen promoted HBsAg reduction and concurrently enhanced HBV-specific T cell responses in patients with chronic hepatitis B

Background PD-1 blockade has emerged as a promising approach for functional cure of chronic hepatitis B (CHB). Objective This study aimed to evaluate the safety profile of anti-PD-1 antibody (αPD-1), ...
gut.bmj

Early high-energy enteral nutrition in acute pancreatitis: overfeeding and respiratory risk in high-risk patients

I read the GOULASH trial with great interest. This multicentre, double-blind randomised clinical trial compared early high-energy enteral nutrition (30 kcal/kg/day) with a gradually increasing energy ...
gut.bmj

Intestinal epithelial vitamin D receptor deletion leads to defective autophagy in colitis

Objective Vitamin D and the vitamin D receptor (VDR) appear to be important immunological regulators of inflammatory bowel diseases (IBD). Defective autophagy has also been implicated in IBD, where ...
gut.bmj

The influence of a preserved colon on the absorption of medium chain fat in patients with small bowel resection

Background—Medium chain C8–C10 triglycerides (MCTs) improve fat absorption in short bowel patients. Effects on overall energy absorption remain unknown. Aims—To determine whether MCTs and medium chain ...
gut.bmj

Role of alkaline phosphatase in colitis in man and rats

Background and aims: Crohn’s disease (CD) and ulcerative colitis (UC) are chronic multifactorial inflammatory bowel diseases (IBDs) with unknown aetiology, but a deregulated mucosal immune response to ...
gut.bmj

Digital twins in IBD--bridging data, biology and trial innovation

Clinical trials in IBD face difficulties of escalating complexity, high costs and challenges in recruitment. Digital twins are virtual, data-driven replicas of individual patients that model disease ...
gut.bmj

The menstrual cycle affects rectal sensitivity in patients with irritable bowel syndrome but not healthy volunteers

Department of Medicine, University Hospital of South Manchester, Manchester M20 2LR, UK Correspondence to: Dr L A Houghton, Department of Medicine, University Hospital of South Manchester, Nell Lane, ...
gut.bmj

Beta human chorionic gonadotropin concentrations in serum of patients with pancreatic adenocarcinoma

a Laboratory of Tumour Immunology, 1st Department of Propaedeutic Surgery, Athens Medical School, Hippokration Hospital, Athens, Greece, b Department of Clinical Oncology, RPMS-Hammersmith Hospital, ...