The San Francisco 49ers are used to playing shorthanded, but this week they will also face a foe that is coming in without ...

The San Francisco 49ers on Saturday elevated Trevis Gipson and Nick Zakelj from the practice squad for Sunday’s game against ...

Preview the Week 8 matchup between the Houston Texans and San Francisco 49ers with predictions, odds, over/under, spread, ...

Kickoff from NRG Stadium is set for 1 p.m. ET, and the Texans are 1.5-point favorites, according to the latest 49ers vs.

Head coach Kyle Shanahan on Friday told reporters wide receiver Brandon Aiyuk is making progress toward a return that could ...

Quarterback Brock Purdy will miss his fourth straight game for the San Francisco 49ers because of a toe injury.

If the 49ers win Sunday in Houston, they’ll match their overall win total from last season and they’ll be alone atop the NFC ...

Saleh might have been the 49ers' top offseason acquisition, and no NFL assistant coach has made a bigger impact this season.

The San Francisco 49ers take on the Houston Texans at 10 a.m. PT on Sunday, Oct. 26 at NRG Stadium in Houston.