Star tight end George Kittle suffered a hamstring injury in the first week of the season that landed him on injured reserve. Wide receiver Jauan Jennings picked up a shoulder injury in Week 1 and was able to battle through it in Week 2 before sitting out Sunday’s win over the Arizona Cardinals.

Nick Bosa suffered a knee injury on Sunday, and while an ACL tear has been ruled out he could still miss time for the 49ers. More at PFR.

Here is where the San Francisco 49ers sit in the NFL Week 4 power rankings after their thrilling win over the Arizona Cardinals.

San Francisco clearly has enough depth to withstand its latest wave of misfortune. Plus, signs of growth from Caleb Williams and the Bengals need major changes.

Undefeated NFC West rivals square off in Week 3 NFL action as the San Francisco 49ers host the Arizona Cardinals. Kyler Murray and the Cardinals face their first division rival of the season after kicking off the 2025 campaign with wins against the New Orleans Saints and the Carolina Panthers.

Catch up on all the NFL action from week three as the Philadelphia Eagles and San Francisco 49ers claim late wins, while the Indianapolis Colts also remain unbeaten.

Olivia Culpo and Christian McCaffrey's daughter Colette, 2 months, attended her first San Francisco 49ers game on Sept. 21, wearing a onesie with her dad's number 23 on the back.

San Francisco stars Christian McCaffrey and Trent Williams speak to reporters after the 49ers' 16-15 win vs. the Arizona Cardinals on Sunday at Levi's Stadium.Trent Williams states 49ers wideout Ricky

Ricky Pearsall is undisputedly the San Francisco 49ers' best offensive weapon this season. We're three weeks into the 2025 season, and his performance against t