Intermittent fasting became one of the most popular nutrition strategies in America because it promises a simple idea: ...

Background Immune checkpoint blockade (ICB) has limited efficacy in microsatellite stable (MSS) colorectal cancer (CRC) due to an immunosuppressive tumour microenvironment. Although loss of ...

Muscles age differently than you think. Discover the science behind the aging muscle paradox—and how exercise can help you ...

Parkinson’s disease (PD) is characterized by the progressive degeneration of midbrain dopaminergic neurons, with apoptosis representing the predominant mechanism of neuronal cell death among the ...

Autophagy—meaning "self-eating" in Greek—is a fundamental cellular mechanism that preserves cell health by recycling and degrading worn-out or dysfunctional components. Serving as an essential ...

ABSTRACT: As a key process in maintaining cellular metabolic homeostasis, the targeted regulation of autophagy offers new insights into the treatment of metabolic disorders such as diabetes, obesity, ...

Metformin is listed as one of the World Health Organization's "essential" medicines. The cheap, generic drug is seen as a global go-to for diabetes treatment.Francis Dean/Deanpictures/Getty A cheap, ...

A new study unravels the relationship between mitofusins (mitochondrial proteins) and autophagy. Using gene editing with CRISPR-Cas9, the team has been able to study these proteins without altering ...

Autophagy, the process by which cells recycle damaged components, has long been associated with neuroprotection. However, the precise mechanisms by which autophagy maintains brain health have remained ...

Recycling takes place in our cells at all times: in a process called autophagy, cell components that are no longer needed are enclosed by membranes and broken down into their basic building blocks.

It's been well known for many decades that exercise provides many benefits to our health. But a new scientific consortium is revealing new insights into just how profound exercise can be for the human ...