Drug Target Review

New BET therapies could help beat resistance in solid cancers

A new review finds that next-generation BET-targeted therapies, including selective inhibitors and PROTACs, are addressing ...
News-Medical.Net

Directed enzyme evolution and the Nobel Prize: Making enzymes evolve in the lab

Frances Arnold on directed enzyme evolution: random mutation plus smart screening, and why it changed enzyme engineering and ...

AI helps scientists improve prediction of which DNA sequences bind to each other

Researchers have demonstrated a novel AI model that can predict which DNA molecules bind with other DNA molecules. A more ...

DNA origami turns secret messages into nano–Morse code that acts as multiplayer molecular encryption

Mathematics has always been at the core of securing information. From online banking to government communications, modern ...
eLife

In silico design and validation of high-affinity RNA aptamers for SARS-CoV-2 comparable to neutralizing antibodies

Computer-Aided Aptamer Modeling and Optimization (CAAMO) enables structure-guided RNA aptamer affinity maturation, producing a SARS-CoV-2 RBD (receptor binding domain) binder that rivals neutralizing ...
Frontiers

Artificial Intelligence for Protein Conformational Analysis, Biomolecular Modeling, and Biomedical Discovery

OverviewProteins are not static molecular objects but dynamic conformational ensembles whose structures, motions, disorder, ...

'Double-donut' structure of SPOP protein reveals mechanism of unexplained cancer mutations

Mutations to the protein SPOP are widespread in cancer, yet many remain poorly understood. To address this gap, St. Jude Children's Research Hospital scientists obtained structures of SPOP in both the ...