Understanding inflammation – and above all, how to regulate it – is one of the great medical challenges of modern medicine ...

Scientists have uncovered the gene-regulation mechanism that determines whether a cell survives or dies when under stress.

New research led by Prof Edward Avezov (UK DRI at Cambridge) reveals how the architecture of the cell’s transport network, the endoplasmic reticulum, can go awry and lead to problems with signalling ...

Neuropeptides are brain and body signaling molecules that shape emotion, pain, metabolism, cognition, and immune function.

The endoplasmic reticulum is usually the biggest organelle in eukaryotic cells; it has various portions that serve different purposes; and it is the site of protein production, as well other other ...

Calcium (Ca 2+) drives many cellular functions, though the way it controls quality of proteins in the endoplasmic reticulum (ER), a cellular organelle that synthesizes and transports proteins, has not ...

The body's cells change their shape to close gaps such as wounds – with part of the cell flexing depending on the curve of the gap and the organization of cell-internal structures, a new study reveals ...

Scientists use math and physics to address the mystery of just how the endoplasmic reticulum, an organelle essential to life at the cellular level, continually re-arranges itself As a second-year Ph.D ...

Inside cells, there exists an extensive system of canals known as the endoplasmic reticulum (ER), which consists of membrane-encased tubes that are partially broken down as needed -- for instance in ...

The ER-phagy receptor FAM134B is initially distributed via the membrane surface (left). Its IDRs move back and forth in a largely disordered manner, like tentacles. The formation of local clusters ...

Background: We identified a family with familial hypercholesterolemia (FH). The proband presented with corneal arcus, skin, and tendon xanthomas, significant stenosis in the coronary circumflex and ...