Illustration of small molecule modulation of β-arrestins and GPCR signaling pathways based on concepts developed by the Lefkowitz Laboratory, Duke University. To function normally, nearly every cell ...

To function normally, nearly every cell in the human body relies on G-protein coupled receptors (GPCRs) to receive and send signals. That's why GPCRs are targeted by roughly one-third of all ...

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Proteins called β-arrestins regulate signalling through members of the G protein-coupled receptor (GPCR) superfamily. Small molecules that bind directly to the β-arrestins and inhibit their activities ...

Developing protein-based ligands for G protein-coupled receptors (GPCRs) is challenging due to the structural complexity, dynamic flexibility and deeply recessed orthosteric binding pockets of these ...

A team led by chemist Frank Glorius, a professor at the Institute of Organic Chemistry at the University of Münster, has ...

To develop new and better peptides, the short amino acid strings behind medicines like GLP-1 drugs, researchers have used AI ...

Researchers writing in Frontiers in Science propose using simple tests to track metabolic health in noncommunicable diseases, ...

Scientists have discovered how chemokines and G protein-coupled receptors selectively bind each other to control how cells move. Scientists from St. Jude Children's Research Hospital and the Medical ...

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