An expanded federal library of chemical fingerprints helps scientists identify unknown substances found in forensic evidence, ...

There was a substantial increase in recent years in the use of a form of the primary medication to treat opioid use disorder, ...

Medications that target depression, anxiety and poor sleep could help treat pain without opioids’ addictive properties A range of other medications could serve as alternatives to powerful opioids for ...

The largest review ever conducted on opioids for acute pain found that these widely prescribed drugs often deliver only small, short-lived benefits. For many common conditions, including some ...

Purdue Pharma, the bankrupted drug manufacturer at the center of the nation’s yearslong opioid epidemic, shut down May 1. The closure is part of a $7.4 billion deal reached after Purdue and the ...

"Year to date" sales for 2023, 2024, 2025, and 2026 sales are shown in series at the top of the table and then just below a comparison of 2026 versus 2025 and 2026 versus 2024 is displayed. This ...

The number of U.S. individuals on long-term opioid therapy fell from 5.6 million in 2015 to 4.2 million in 2023. Co-prescribing opioids with gabapentinoids increased, however, reaching 58.7% in 2023.

Multiple states have raised the alarm in the past month about cychlorphine, a synthetic opioid tied to several dozen recent overdoses that is far stronger than fentanyl. Cychlorphine is part of a new ...

While prescribing peaked more than a decade ago, in 2012, a legacy effect is still underway, with widespread misuse of synthetic opioids (chiefly fentanyl) replacing their prescribed counterparts as ...

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While the dangers of fentanyl have been dominating headlines for years, the death toll from another class of extremely potent synthetic opioids called “nitazenes” has been climbing steadily. For ...

This Journal feature begins with a case vignette highlighting a common clinical problem. Evidence supporting various strategies is then presented, followed by a review of formal guidelines, when they ...