Here is where the San Francisco 49ers sit in the NFL Week 4 power rankings after their thrilling win over the Arizona Cardinals.

Purdy has missed the last two games after suffering a turf toe injury in San Francisco’s Week 1 win against the Seattle Seahawks. While he wasn’t able to play against the Cardinals, Purdy is expected to return to the field in Week 4 when the 49ers take on the Jacksonville Jaguars, according to NFL Network’s Ian Rapoport.

Catch up on all the NFL action from week three as the Philadelphia Eagles and San Francisco 49ers claim late wins, while the Indianapolis Colts also remain unbeaten.

Undefeated NFC West rivals square off in Week 3 NFL action as the San Francisco 49ers host the Arizona Cardinals. Kyler Murray and the Cardinals face their first division rival of the season after kicking off the 2025 campaign with wins against the New Orleans Saints and the Carolina Panthers.

San Francisco clearly has enough depth to withstand its latest wave of misfortune. Plus, signs of growth from Caleb Williams and the Bengals need major changes.

The San Francisco 49ers and Arizona Cardinals will meet on Sunday. Here's what fantasy owners should do with their 49ers in Week 3.